EndoBarrier Overview | United Kingdom
Like you, more than 160 million people worldwide face the dual challenge of managing type 2 diabetes and excess weight.1,2,3 Medications and surgery may help initially but, these may become less effective over time.4,5 In addition, these options carry side effects and may require a life-long commitment to dosing regimens or dietary restrictions.4,5 EndoBarrier Therapy is a non-surgical means of controlling your type 2 diabetes and obesity. This clinically proven therapy allows you to control your blood sugar and lose weight without any permanent changes to your anatomy.
About the EndoBarrier® liner
The EndoBarrier liner is a thin flexible tube that fits inside your intestine (below your stomach) creating a physical barrier between the intestinal wall and the food you eat. The liner is flexible and moves with your body after placement. Once the liner is placed, most patients report that they begin to experience results within two weeks.6 These results may include:
- Reduced blood-sugar (also called’blood glucose’) levels
- Feelings of fullness (satiety)
- Weight loss
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How It Works
As part of the natural digestive process, partially digested food mixes with several substances produced by your body. Some of these substances are bile, enzymes, and hormones. Once the EndoBarrier liner is placed, partially digested food passes through its center, but it is not allowed to mix with these substances until food has passed completely through the liner. This effects interactions with hormones in the intestine and increases satiety – the feeling of being satisfied with the amount you have eaten – which results in reduced food intake. Clinical data also suggests an effect on the hormones related to your body’s regulation of insulin and blood-sugar as part of this process, which assist in controlling your diabetes.6 This may result in an ability to reduce your diabetes medications.
EndoBarrier Liner Placement and Removal
Placing the EndoBarrier liner is a simple procedure that does not require any incisions. Your doctor will place the liner in your upper intestine through your mouth. Once in place, the liner will conform with the shape and movement of your intestine and begins to work immediately. The EndoBarrier liner must be removed at the end of your treatment period which may not exceed 12 months. Liner removal is done via another brief, incision-less, procedure, similar to the one you experienced during placement. There will be no scars. You will likely be able to go back to your normal routine after a brief recovery.
It is important to discuss all available treatment options and their risks and benefits with your doctor. EndoBarrier Therapy, in conjunction with lifestyle changes and the guidance of your medical team, can lead to regained control of your type 2 diabetes and weight.
To find a doctor that offers EndoBarrier Therapy near you, please visit find a physician.
The GI Dynamics’ EndoBarrier® Gastrointestinal Liner System is used for the treatment of obese type 2 diabetes with BMI ≥ 30 kg/m2, or obese patients with BMI ≥ 30 kg/m2 with ≥ 1 co-morbidities, or obese patients with BMI >35 kg/m2. The liner is indicated for maximum implant duration of 12 months. EndoBarrier is not approved for sale in the U.S. and is limited by federal law to investigational use only in the United States.
1. Finucane, Mariel M., et al, National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. The Lancet, Vol 377, February 12, 2011, pp 557-567.
2. The Global Burden: Diabetes and Impaired Glucose Tolerance. IDF Diabetes Atlas, Sixth Edition, pp 32-50.
3. Ninh T. Nguyen, et al, Relationship Between Obesity and Diabetes in a US Adult Population: Findings from the National Health and Nutrition Examination Survey, 1999–2006. Obes Surg 2011, 21:351-355.
4. Fonseca, V. “Defining and characterizing the progression of type 2 diabetes.” British Journal of Diabetes & Vascular Disease 2008, 8(2), S3-S8.
5. Courcoulas, A., et al, “Weight Change and Health Outcomes at 3 Years After Bariatric Surgery Among Individuals With Severe Obesity,” Journal American Medical Assoc. 2013 310(22):2416-25.
6. de Jonge C, et al, “Endoscopic Duodenal-Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes.”, Obesity Surgery, Sept. 2013, Volume 23, Issue 9, pp 1354-1360.